Endocrine Abstracts

We have evaluated the effectiveness of radiotherapy in three patients with recurrent symptomatic hypophysitis following surgical decompression.Case 1(54 F); presented with diabetes insipidus, hypopituitarism and a large hypophyseal mass. Following trans-sphenoidal surgery (TSS), a diagnosis of xanthomatous hypophysitis was made. Two years later severe headaches returned, and despite a second trans-sphenoidal procedure, visual acuity further deteriorated in the left eye...

Background: Glucocorticoids play a key role in determining body fat distribution. Excess circulating glucocorticoids lead to intrahepatic fat accumulation. Obesity is associated with enhanced glucocorticoid production but this is offset by enhanced degradation such that circulating steroid concentrations are normal. However, tissue-specific pathways may lead to different degrees of cortisol exposure in different organs. Local steroid exposure in the liver is determined by the ...

Background: The gut hormone PYY3-36 (PYY) is released into the circulation after eating and physiologically inhibits food intake. Obese and lean subjects are equally sensitive to this effect, however fasting levels of PYY are reduced in obese subjects.Methods: We investigated the postprandial PYY response and satiety response using a visual analogue scale (VAS) to 6 test meals of increasing calorie content in 20 lean and 20 obese subjects. We also infuse...